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Integrative Imaging: from Molecule to Organism - Institut Curie / Inserm Unit 759
Keywords :
electron tomography, SIMS imaging, magnetic resonance imaging, image processing, structural biochemistry, in vivo
Unit director: Sergio Marco
The combination of competences coming from various disciplines of science is becoming essential for the technological development and the fundamental research. Particularly, in life sciences, the comprehension of biological processes requires the combination of knowhow coming from biology, biochemistry, molecular biology, physics, chemistry, medicine, mathematics and data-processing engineering. Certain countries, major actors in the international research, conscious that the comprehension of biological process passes by understanding the structure-function relationships between the different implicated partners, are setting up research centers combining these disciplines. A major limitation to success in this approach is that the competences and equipments required are dispersed in several sites, limiting the efficiency of collaborative projects and the transfer of developments to industrials. Since 2006, funding date of the U759 unit, we work to group in a single place the actors able to understand the languages of different disciplines and the equipments required to set-up interconnected projects for the development of multimodal imaging in order to increase the efficiency in the development of products that can contribute to the understanding of the structure-function relationships of biological components.
Presently, the Integrative Imaging Unit combine competences for image analysis in biology from different disciplines (cancerology, cell biology, biophysics, biochemistry, computer sciences) in order to develop, set-up and apply efficient tools for the study of tumor morphogenesis and diagnosis, for the follow-up of therapeutic agents and for the structural characterization of subcellular organelles. In addition, U759 have complete, in December 2009, the equipments already present in the unit (transmission electron microscope Philips 201, ionic probe Cameca Nano-SIMS 50, two MRI systems, Bruker Biospec 4.7 Tesla and Varian IRM 9.4 Tesla, a NMR spectrometer 11.7 Tesla 500 MHz proton, a circular dichroïsm Jasco J-710 and a micro-calorimeter Microcal VP-ITC) by an analytical cryo-electron microscope (EFTEM, STEM 200KV FEG Jeol 2200FS) equipped for tomography.
On the basis of the studied processes and of the methods applied for their study the U759 is organized in three research groups:
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Molecular bases of the cellular functions of proteins
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Structural bases of cellular processes
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In vivo functional and molecular MRI
